The Science behind

the Technology


Do you know how your brain is doing?

The science behind the NeuroCatch® Platform addresses this critical question with the scientific discovery and development of the brain vital signs framework. NeuroCatch® enables a rapid, objective evaluation of brain activity, acquired using event-related potentials (ERPs), for sensitive and objective evaluation of cognitive function.

NeuroCatch® offers a scientific, evidence-based approach for the clinical utilization of ERPs. What are ERPs? ERPs are long-standing, extensively studied brain activity responses linked to cognitive function. These vital responses allow for objective evaluation of Auditory sensory, Basic attention, and Cognitive processing, which can be used to optimize individual brain health and guide brain care in conditions like brain injury, mental health, and neurological diseases.


Learn More

Progression from EEG
to the NeuroCatch® Platform
EEG
  • Advanced electroencephalography (EEG)
  • Objective neurophysiological results
  • Rapid and accessible cognitive assessment
 
 
ERP
  • Event-related potentials, derived from EEG[1]
  • ERPs track cognitive information processing[2]
ABC
  • Auditory sensory processing
  • Basic attention processing
  • Cognitive processing
 
 
 
NeuroCatch® Platform
  • Integrated software and hardware solution
  • Automated acquisition, analysis, reporting, and management of results
  • Rapid objective evaluation of cognitive function accessible to clinics
 

Stimulating
Cognitive Responses


Unique to NeuroCatch® is the evidence-based method to stimulate specific brain responses involved in cognition. Using a rapid 6-minute simple auditory sequence of basic tones and word pairs it is possible to reliably determine the speed and size of these standard brain responses within an individual.

The results from NeuroCatch® are immediate and easy to use. They take complex neuroscience and translate it into simple brain health results. The clinical report is anchored by an intuitive graphic of cognitive brain health. Detailed results on the speed and size of the three different brain responses make up the ABCs of NeuroCatch® (below). The ABCs can be compared to standardized normative data to evaluate individual results[3].

 
 
Image
 


Evolution of

the Brain Vital Signs Scientific Framework and the NeuroCatch® Platform



Image


The

Early Days


With the earliest evoked responses reported in 1939 and nearly 150,000 published studies in the National Library of Medicine’s PubMed.gov database, the foundational work to ensure that ERP research advances could be made clinically accessible as an objective measure of cognitive function began in the mid-1990s. By the mid-2000s, numerous benchmarking studies were published in international peer-reviewed journals demonstrating that these ERPs could be linked to established clinical neuropsychological tests. Clinically, however, ERP testing remained inaccessible because of practical barriers. It was time-consuming, onerous, and required specialized expertise to understand the results, which were complex and not clinically standardized.

To move from a research laboratory procedure to a regulatory approved clinical test, the ERP procedure was translated in 2010 to a rapid, semi-automated, point-of-care test called the Halifax Consciousness Scanner or HCS. The HCS enabled proof-of-concept studies in acquired brain injury patients within numerous clinical settings, demonstrating that ERPs could be taken out of the research setting and be accessible for point-of-care.


Brain

Vital Signs


The concept of brain vital signs came from the realization that the progress in using ERPs at point-of-care created the opportunity to envision a vital sign framework for brain function. From 2010 to present, studies have demonstrated that it was possible to refine the prior HCS protocol to move to a standardized evaluation of the peak timing and amplitudes of the N100, P300, and N400 responses. These ERP responses were transformed into a clinical ABC framework and plotted on as a healthy, normal hexagon shape using a radar plot. The brain vital sign responses were reliably measured across age ranges and more sensitive than subjective, error-prone behavioural tests to detecting changes in healthy aging, concussion, sub-concussion, moderate-severe brain injury, dementia and other neurological and mental health conditions.

The NeuroCatch® Platform represents the technology implementation of brain vital sign research, which is fully automated to provide the highest quality, most accessible and advanced capabilities across a range of clinical points-of-care. NeuroCatch® is rigorously developed, tested, and regulatory approved for use in brain health and optimization.

 
Completed and Ongoing
Clinical Studies

Using the NeuroCatch® Platform
 

STUDY TITLE STATUS CONDITIONS LOCATION REG. NO.
Assessing Repeatability of NeuroCatch™ Platform Measurements: An Initial Assessment Completed - Brain Health HEALTHTECHCONNEX INC.

Centre for Neurology Studies
Surrey, British Columbia, Canada
ClinicalTrials.gov:
NCT03421405
Preparing to Treat Concussions in Hockey Players Using a “From Ice to Axon and Astrocyte Repeated Measures Design” Recruiting Complete - Traumatic Brain Injury

- Concussion
Mayo Clinic


Rochester, Minnesota, USA
Site IRB:
18-004925
Development of a Reference Interval Database With the NeuroCatch™ Platform Recruiting - Children, Only


- Traumatic Brain Injury

- Concussion, Mild

- Pediatric ALL
HEALTHTECHCONNEX INC.

Centre for Neurology Studies
Surrey, British Columbia, Canada
ClinicalTrials.gov:

NCT03835962
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion Recruiting - Children, Only


- Traumatic Brain Injury

- Concussion, Mild

- Pediatric ALL
ALBERTA CHILDREN'S HOSPITAL, Department of Paediatrics

Calgary, Alberta, Canada
ClinicalTrials.gov:


NCT03889483
Assessing Brain Changes Throughout the WCBH Program Recruiting - Brain Injuries HEALTHTECHCONNEX INC.

Centre for Neurology Studies
Surrey, British Columbia, Canada
ClinicalTrials.gov:


NCT03889483
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease Recruiting - Alzheimer Disease


- Dementia


- Neuropathology


- Mild Cognitive Impairment
BRUYERERESEARCH INSTITUTE

Ottawa, Ontario, Canada
ClinicalTrials.gov:


NCT03676881
study title
status
conditions
location
CT Registry
Completed
Brain Health
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03421405

Recruiting Complete

Traumatic Brain Injury

Concussion

MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA
Site IRB:
18-004925
Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03835962

Recruiting

Traumatic Brain Injury

Concussion, Mild

Pediatric

ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada

ClinicalTrials.gov:
NCT03889483

Recruiting
Brain Injuries
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada

ClinicalTrials.gov:
NCT03438851

Recruiting

Alzheimer Disease,

Dementia

Neuropathology

Mild Cognitive Impairment

BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada

ClinicalTrials.gov:
NCT03676881

study title
status
conditions
location
reg. no.
STATUS
Completed
CONDITIONS
Brain Health
LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03421405
STATUS
Recruiting Complete
CONDITIONS

Traumatic Brain Injury, Concussion

LOCATION
MAYO CLINIC
Centre for Neurology Studies
Rochester, Minnesota, USA
REG. NO.
Site IRB:
18-004925
STATUS
Recruiting
CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03835962
STATUS
Recruiting
CONDITIONS

Children Only, Traumatic Brain Injury, Concussion Mild, Pediatric ALL

LOCATION
ALBERTA CHILDREN'S HOSPITAL
Department of Paediatrics
Calgary, Alberta, Canada
REG. NO.
ClinicalTrials.gov:
NCT03889483
STATUS
Recruiting
CONDITIONS
Brain Injuries
LOCATION
HEALTHTECH CONNEX INC.
Centre for Neurology Studies
Surrey, British Columbia, Canada
REG. NO.
ClinicalTrials.gov:
NCT03438851
STATUS
Recruiting
CONDITIONS

Alzheimer Disease, >Dementia, Neuropathology, Mild Cognitive Impairment

LOCATION
BRUYERE RESEARCH INSTITUTE
Ottawa, Ontario, Canada
REG. NO.
ClinicalTrials.gov:
NCT03676881

Peer Reviewed
Reference Literature


Intended Use

The NeuroCatch® Platform is intended for the elicitation, acquisition, analysis, storage, reporting and management of electroencephalograph (EEG) and event-related potential (ERP) information.

FOOTNOTES
[1] Luck, Steven J. An Introduction to the Event-Related Potential Technique, Second Edition. Cambridge: MIT Press (2014)

[2] Duncan, C. C. et al. Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Neurophysiol Clin 120, 1883–1908 (2009)

[3] Van Dinteren R, Arns M, Jongsma MLA, Kessels RPC. Development across the lifespan: a systematic review and meta-analysis. PLoS One. doi:10.1371/journal.pone.0087347 (2014)