The Science Behind the Technology

A scientific, evidence-based approach for the clinical utilization of ERPs

Learn More

The Science Behind the Technology

A scientific, evidence-based approach for the clinical utilization of ERPs

Learn More

Progression from EEGs to the NeuroCatch™ Platform

EEG

  • Objective
  • Neuro-physiological cognitive assessment

ERP

  • Event-Related Potentials (ERPs) are derived from EEG recordings[1]
  • ERPs are sensitive to variables related to information processing[2]

ABC

  • A = Auditory Sensation (N100)
  • B = Basic Attention (P300)
  • C = Cognitive Processing (N400)

NeuroCatch™ Platform

  • Software + hardware
  • Elicits, acquires, analyzes, stores, reports, and manages ERP info for ABC
  • Accessible to clinics

The NeuroCatch™ Platform provides:

A scientific, evidence-based approach for the clinical utilization of ERPs

An objective, neuro-physiological assessment using ABC (Auditory Sensation [N100]; Basic Attention [P300]; and Cognitive Processing [N400])

Evolution of the Brain Vital Signs™ Framework

Spearheaded by leading Simon Fraser University neuroscientist Dr. Ryan D’Arcy, HealthTech Connex is working to deliver Brain Vital Signs™, a new framework for analyzing complex brainwave data that will provide simple, practical and objective physiological markers of brain function. Learn more about Brain Vital Signs™.

Completed and Ongoing Clinical Studies

Using the NeuroCatch™ Platform

Study Title Status Conditions Location Reg. No.
Assessing Repeatability of NeuroCatch™ Platform Measurements: An Initial Assessment Completed
  • Brain Health
 HealthTechConnex Inc. Centre for Neurology Studies
Surrey, British Columbia, Canada		 ClinicalTrials.gov:
NCT03421405
Preparing to Treat Concussions in Hockey Players Using a “From Ice to Axon and Astrocyte Repeated Measures Design” Recruiting Complete
  • Traumatic Brain Injury
  • Concussion
 Mayo Clinic
Rochester, Minnesota, USA		 Site IRB:
18-004925
Development of a Reference Interval Database With the NeuroCatch™ Platform Recruiting
  • Brain Health
 HealthTechConnex Inc. Centre for Neurology Studies
Surrey, British Columbia, Canada		 ClinicalTrials.gov:
NCT03835962
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion Recruiting
  • Children, Only
  • Traumatic Brain Injury
  • Concussion, Mild
  • Pediatric ALL
 Alberta Children’s Hospital, Department of Paediatrics
Calgary, Alberta, Canada		 ClinicalTrials.gov:
NCT03889483
Assessing Brain Changes Throughout the WCBH Program Recruiting
  • Brain Injuries
 HealthTechConnex Inc. Centre for Neurology Studies
Surrey, British Columbia, Canada		 ClinicalTrials.gov:
NCT03889483
Longitudinal Validation of a Computerized Cognitive Battery (Cognigram) in the Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease Recruiting
  • Alzheimer Disease
  • Dementia
  • Neuropathology
  • Mild Cognitive Impairment
 BruyereResearch Institute
Ottawa, Ontario, Canada		 ClinicalTrials.gov:
NCT03676881
Research Library

Peer Reviewed Background Papers

N100

i

The N1 Response and Its applications

Hyde 1999

i

The N100 auditory cortical evoked potential indexes scanning of auditory short-term memory

Conley 1999

P300

i

Clinical application of the P300 event-related brain potential

John Polich 2004
i

Updating P300: An Integrative Theory of P3a and P3b

John Polich 2007

N400

i

Thirty years and counting: Finding meaning in the N400 component of the event related brain potential

Marta Kutas & Kara D. Federmeier 2011
i

Electrophysiological assessment of language function following stroke

D’Arcy et al. 2003

Brain Vital Signs

i

Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework

Hajra et al 2018
i

Brain vital signs detect concussion-related neurophysiological impairments in ice hockey

Fickling et al 2019
i

Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time

Hajra 2016

Learn More

Learn more about the platform and the next steps if you are interested in incorporating this technology into your research studies.

[1] Luck, S. J. An Introduction to the Event-Related Potential Technique. (MIT Press, 2014)

[2] Duncan, C. C. et al. Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Neurophysiol Clin 120, 1883–1908 (2009)